腫瘤學(xué)

封面介紹：Diffuse large B-cell lymphoma（DLBCL）is the most common subtype of non-Hodgkin's lymphoma，constituting 30% to 40% of all adult non-Hodgkin's lymphoma cases in China. The response to treatment is an important Fluorine-18 fluorodeoxyglucose（18F-FDG）positron emission tomography/computed tomography（PET/CT）is a powerful tool both for primary staging and for monitoring the response to therapy in DLBCL and is used in the standardized response assessment criteria for lymphoma. The cover art shows the image of18F-FDG PET/CT scans of DLBCL with a score of 4. For more details，please read the article on pages 264-271.

Qualitative visual trichotomous assessment improves the value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in predicting the prognosis of diffuse large B-cell lymphoma

ZHANG Xu，F(xiàn)AN Wei，HU Ying-ying，et al.

Fluorine-18 fluorodeoxyglucose（18F-FDG）positron emission tomography/computed tomography（PET/CT）is a powerful tool for monitoring the response of diffuse large B-cell lymphoma（DLBCL）to therapy，but the criteria to interpret PET/CT results remain under debate. We investigated the value of post-treatment PET/CT in predicting the prognosis of DLBCL patients when interpreted according to qualitative visual trichotomous assessment（QVTA）criteria compared with the Deauville criteria. Methods： In this retrospective study，final PET/CT scans of DLBCL patients treated with rituximab-based regimens between October 2005 and November 2010 were interpretedusing the Deauville and QVTA criteria. Survival curves were estimated using Kaplan-Meier analysis and compared using the log-rank test. Results： A total of 253 patients were enrolled. The interpretation according to the Deauville criteria revealed that 181 patients had negative PET/CT scan results and 72 had positive results. The 3 year overall survival（OS）rate was significantly higher in patients with negative scan results than in those with positive results（91.6% vs. 57.5%，P ＜ 0.001）. The 72 patients with positive scan results according to the Deauville criteria were divided into two groups by the interpretation according to the QVTA criteria： 29 had indeterminate results，and 43 had positive results. The 3 year OS rate was significantly higher in patients with indeterminate scan results than in those with positive results（91.2% vs. 33.5%，P ＜ 0.001）but was similar between patients with negative and indeterminate scan results（91.6% vs. 91.2%，P=0.921）. Conclusions： Compared with the Deauville criteria，using the QVTA criteria for interpreting post-treatment PET/CT scans of DLBCL patients is likely to reduce the number of false positive results. The QVTA criteria are feasible for therapeutic outcome evaluation and can be used to guide risk-adapted therapy.

Diffuse large B-cell lymphoma； Positron emission tomography/computed tomography（PET/CT）； Prognosis； The qualitative visual trichotomous assessment（QVTA）criteria； The Deauville criteria

來(lái)源出版物：Chinese Journal of Cancer，2015，34（6）： 264-271聯(lián)系郵箱：Wei Fan，fanwei@sysucc.org.cn