GCMS-QP2010

The GCMS-QP2010 Ultra is our most advanced gas chromatograph mass spectrometer. Descended from the GCMS-QP2010 Plus, it features best-in-class scan speed and sensitivity. A newly designed and patented technology called ASSP? (Advanced Scan Speed Protocol) allows this GC-MS to scan at 20,000 u/sec without sensitivity loss or spectral distortion.

High-Sensitivity Measurement

High-sensitivity ion source provides an ion optics system with high transport efficiency and achieves temperature homogenization of the ion source box.

High-Speed Scanning

Equipped with high-speed data acquisition and processing via the newly developed ASSP? function, improves sensitivity at elevated scan speeds (above 10,000 u/sec).

Scan/SIM Measurement (FASST)

FAAST (Fast Automated Scan/SIM Type) is a data acquisition technique that allows the user to collect Scan data and SIM data in a single analysis. ASSP? has improved this process by allowing the SIM dwell times to be shortened by as much as 5X without sacrificing sensitivity, allowing the user to monitor more SIM channels.

Easy sTop

Easy sTop enables users to perform maintenance on the injection port without venting the MS so downtime is minimized.

Twin Line MS System (optional)

The GCMS-QP2010 Ultra is capable of accepting installation of two narrow-bore capillary columns into the MS simultaneously. This allows you to switch applications without physically modifying the column installation.

Ecology mode

Equipping the instrument with Ecology mode reduces the power and carrier gas consumed in analysis standby mode.

You can compare running costs and CO2emissions output between new and previous models. Please click the banner below for ecology simulation in your laboratory.

Published papers by using GCMS-QP2010

1. Feijin Peng, et al. Determination of DHA and linoleic acid contents in infant formula milk powder by GC-MS. Food Science, 2011, 32:261-263.

2. Jijin Liu, et al. GC-MS determination of 14 sedativehypnotic drugs illegal mixed in traditional Chinese medicines and health foods. Chinese Journal of Pharmaceutical Analysis, 2011, 31:376-379.

LCMS-8030

Triple Quadrupole Mass Spectrometry is the method of choice for accurate quantification and confirmation of trace level analytes in complex matrices. The LCMS-8030 couples the power of a Triple Quadrupole Mass Spectrometer with unparalleled speed to provide the ideal compliment to both UHPLC and HPLC systems. With Ultra Fast MRM transitions and Ultra Fast polarity switching, LCMS-8030 is truly a universal detector for UHPLC or HPLC.

Explanation of LCMSMS terminology MRM

In multiple reaction monitoring (MRM), a specific ion (precursor ion) is selected in Q1 (first stage MS) from among various ions ionized by the ionization probe, the ion is destructed (collision-induced dissociation) in the collision cell (Q2, collision chamber), and a specific ion is detected from among the destructed ions (product ions) in Q3 (second stage MS). Multiple channels can be set in one measurement. For further details, please click here.

User-Friendly

The Strength of a Single-vendor Solution Results in Seamless Operation

· Minimize Instrument Downtime with Easy Maintenance

· Single-vendor Solution Provides Seamless Operation

· Quantitation Browser for Effective Multi-analyte Quantitation

Method Packages

In accordance with regulations, the analysis of trace amounts of components containing many contaminants is now required for residual pesticides in foods and veterinary drugs. LC/MS/MS is often used for these analyses. These method packages are pre-registered with the analysis conditions and compound information of target components. Analysis can now be started without performing difficult or time-consuming tasks required in LC/MS/MS analysis, such as evaluating the separation conditions and optimizing the MS parameters for each compound, to allow efficient batch analysis of multiple components.

Ultra-High Speed

Introducing the Next Generation Triple Quadrupole Technology

High Reliability

Even during Ultra Fast Measurements, the LCMS-8030 Provides Reliable and Reproducible Data

· Robust System Provides Long-term Data Stability

· UFsweeper? Technology Dramatically Minimizes Cross Talk

· Excellent Linearity with Wide Dynamic Range

Published papers by using LCMS-8030

1. Jiaping Li. Technologies and applications of Shimadzu new organic mass spectrometry. Modern Scientific Instruments, 2011, 5:166-170.

2. Eric G. Mohler, et al. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology, 2011, online, DOI: 10.1007/s00213-011-2518-7.

3. Louis-Philippe Morin, et al. Reliable procedures to evaluate and repair crosstalk for bioanalytical MS/MS assays. Bioanalysis, 2011, 3: 275-283.

LCMS-IT-TOF

The LCMS-IT-TOF is a new type of mass spectrometer that combines QIT (ion trap) and TOF (time-of-flight) technologies. When combining QIT and TOF, the greatest technological challenges were the efficient introduction of ions into the QIT and the simultaneous ejection of trapped ions to the TOF. Here, we introduce the newly developed technologies used to solve these problems. The source design, desolvation capillary and reduced collision ion focusing Q-Array were adapted from Shimadzu's successful single-quad HPLC mass spectrometer. The Octapole Lens can introduce eluted ions from the LC to the ion trap by CII (Compressed Ion Injection) method efficiently. The ion trap QIT gives an efficient MSncapability with our new cleaning technology. In addition, BIE (Ballistic Ion Extraction) technology, provides high resolution/accuracy for all MS, MSn... modes. The temperature control of the flight tube gives a mass stability with stabilizing the length of the ion flight and ion acceleration voltage which affects the mass stability. Dual-Stage Reflectron gives an excellent resolution with optimizing energy absorption and time convergence.

High resolution & High precision in MSn measurement

The stable high-resolution spectra achieved throughout a wide mass range and high precision MSndata are derived from the DSR: Dual-Stage Reflectron and the use of BIE: Ballistic Ion Extraction.

These instrument advances can strongly assist in the use of MS for predicating accurate structural details.

High Throughput

Increased amounts of information are obtained for each measurement enabling much higher reliability in structural analysis. High-throughput analysis can be realized with the world's best performance hybrid MS used for structural analysis in terms of high-speed mass spectrum measurement and high-speed ion polarity switching.

High Sensitivity

High-Sensitivity detection of low concentration samples is derived through the use of Compressed Ion Injection (CII) within the ion optics, allowing for the ions to be placed efficiently into the ion trap.

Published papers by using LCMS-IT-TOF

1. Qundi Liu, et al. High-speed counter-current chromatography preparation and separation of naringin, meranzin hydrate and isomeranzin from Exocarpium Citri Grandis. Chinese Journal of Pharmaceutical Analysis, 2011, 31:831-834.

2. Hong Chang, et al. Isolation and identification of anthocyanins in the fruits of Prunus Humilis Bunge. Food Science, 2011, 32:59-63.

3. Naoko Yoshinaga, et al. Fatty acid amides, previously identified in caterpillars, found in the cricket teleogryllus taiwanemma and fruit fly drosophila melanogaster larvae. Journal of Chemical Ecology, 2007, 33:1376-1381.

NEXERA UHPLC System

Nexera is an all-round LC system like no other and is truly worthy of being called a next-generation UHPLC system. It uses revolutionary technology to offer highperformance ultra-high speed LC analysis and the fl exibility to allow confi guring systems for a wide range of applications, such as systems for general-purpose analysis or green LC systems that reduce the usage of organic solvents.

The Only no compromise UHPLC system High speed

High-speed injection, extra-low gradient delay volume combined with the lowest carryover without rinsing enable ultra-high-speed cycle time.

High resolution

Widest pressure/fl ow range (130 MPa up to 3 mL/min) allows for the use of long small-particle columns to maximize peak capacity.

Flexibility & expandability

Modular design, pre-treatment autosampler, and valve options enable a wide variety of system confi gurations, including 2D, method development, and applicated systems.

Reliability & dependability

Engineered using the core competencies of Shimadzu's experience, Nexera provides superior data quality, robustness, and long-term performance.

Published papers by using NEXERA UHPLC System

1. Szabolcs Fekete, et al. The impact of extra-column band broadening on the chromatographic effi ciency of 5cm long narrow-bore very effi cient columns. Journal of Chromatography A, 2011, 1218:5286-5291.

2. Tamara P. Kondratyuk, et al. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Molecular Nutrition & Food Research, 2011, 55(8):1249-1265.

3. Michelle L. Colgrave, et al. What is in a beer?

Proteomic characterization and relative quantifi cation of hordein (gluten) in beer. Journal of Proteome Research, 2012, 11(1): 386-396.