UNSW Department of Surgery, St George Hospital, Kogarah NSW 2217, Australia

Peritonectomy HIPEC—contemporary results, indications

David L. Morris

UNSW Department of Surgery, St George Hospital, Kogarah NSW 2217, Australia

Corresponding to:David L. Morris, Professor of Surgery. UNSW Department of Surgery, St George Hospital, Kogarah NSW 2217, Australia. Email: David.Morris@unsw.edu.au.

Submitted Jul 10, 2012. Accepted for publication Jul 29, 2013.

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Paul Sugarbaker’s procedural description in this paper (1) comes from the pioneer and master of this area. His original description of peritoneal cancer index (PCI) and cytoreduction score (CC) is also fundamental to selection of patients and intraoperative assessment. PCI is calculated by dividing the abdomen into 9 areas and 4 additional scores for the small bowel (Figure 1).

Figure 1 the abdomen is divided into 9 areas and 4 additional scores for the small bowel

Each area is given a score of 0 = nil, 1 ≤0.5 cm, 2 =0.5-5.0 cm, and 3 ≥5.0 cm. A maximum score of 39 may be achieved. PCI is fundamental in selecting patients for surgery, and radiological PCI often underestimates disease.

Completeness of CC is done at the completion of CC0 = nil, CC1 ≤0.25 cm, CC2 =0.25-2.5 cm, and CC3 ≥2.5 cm.

There are other systems but PCI and CC are fundamental to peritonectomy.

The principal current indications forperitonectomy/HIPEC

Pseudomyxona peritoneii (PMP) or jelly belly

We now have published data on well over two thousand patients (2). High PCI is prognostic of operative time and morbidity but is still associated with good long-term outcome.

5- and 10-year survival in 81% and 70% of patients with disseminated peritoneal adeno mucosis (DPAM) was seen.

Appendix adenocarcinoma (PMCA) (whether appearing

like PMP or not).

Results are considerably better than in colorectal cancer with a 49% 5-year survival in our unit. We do not decline patients with high PCI provided CC0 can been achieved.

Peritoneal mesothelioma

This has to be one of the most exciting areas of surgical oncology. A previously invariably fatal disease is now treated with a 50% 5-year survival after peritonectomy/HIPEC (3). Epithelial subtype, completeness of cytoreduction and absence of lymph nodes are positive prognostic factors.

Colorectal cancer

It is now well established that a significant proportion of suitable patients with low volume PC from CRC with complete cytoreduction/HIPEC can achieve long-term survival (2) (PCI ＜15 with approximately 30% at 5 years and if the PCI is ＜10, 50% has been achieved in several centres).

A more contemporary issue is of “prophylactic” HIPEC.

Systematic second look surgery + HIPEC 1 year after resection of high risk CRC revealed PC in 56% which was resected and all patients received HIPEC. 5-year survival was 90% (Elias 2011).

A case control study in similar patients yielded a 4% peritoneal recurrence rate in HIPEC patients and 22% in controls (P＜0.05) (4). The literature would indicate thatlimited and resected peritoneal disease on the primary specimen, ovarian metastasis and perforated tumors are at high risk and should be considered for prophylactic HIPEC.

Ovarian cancer

Whilst there is level one evidence of survival advantage of intraperitoneal chemotherapy in ovarian cancer it is currently remarkably little used (5) despite a 21% reduction in risk of death (6).

HIPEC has the advantage of not requiring post operative intraperitoneal chemotherapy and in a small case/control study achieved significantly lower recurrence and better survival (7).

What is also exciting is that platinum resistance does not preclude excellent results of HIPEC with no difference in 5-year survival in 245 platinum sensitive/resistant patients at approximately 40% (8).

Gastric cancer

Whilst we must accept that this is an awful disease, peritonectomy/HIPEC is the only chance of 5-year survival and this has been reported in 23% and 27% (9,10). Low PCI seems to be very important (we use 10 as a cutoff).

Learning curve

As well as the impressive survival prospects offered by peritonectomy/HIPEC morbidity and particularly mortality has progressively fallen in the major units in the world and several learning curve papers have been published (11,12).

PSOGI our International Organisation recommends a 1 year Fellowship on a high volume unit as part of training.

Acknowledgements

Disclosure: The author declares no conflict of interest.

1. Sugarbaker PH. Cytoreductive surgery using peritonectomy and visceral resections for peritoneal surface malignancy. Transl Gastrointest Cancer 2013;2:54-74.

2. Chua TC, Moran BJ, Sugarbaker PH, et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol 2012;30:2449-56.

3. Yan TD, Deraco M, Baratti D, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol 2009;27:6237-42.

4. Sammartino P, Sibio S, Biacchi D, et al. Prevention of peritoneal metastases from colon cancer in high-risk patients: preliminary results of surgery plus prophylactic HIPEC. Gastroenterol Res Pract 2012;2012:141585.

5. Chan DL, Morris DL, Rao A, et al. Intraperitoneal chemotherapy in ovarian cancer: a review of tolerance and efficacy. Cancer Manag Res 2012;4:413-22.

6. Jaaback K, Johnson N, Lawrie TA. Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer. Cochrane Database Syst Rev 2011;(11):CD005340.

7. Fagotti A, Costantini B, Petrillo M, et al. Cytoreductive surgery plus HIPEC in platinum-sensitive recurrent ovarian cancer patients: a case-control study on survival in patients with two year follow-up. Gynecol Oncol 2012;127:502-5.

8. Bakrin N, Cotte E, Golfier F, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for persistent and recurrent advanced ovarian carcinoma: a multicenter, prospective study of 246 patients. Ann Surg Oncol 2012;19:4052-8.

9. Yonemura Y, Kawamura T, Bandou E, et al. Treatment of peritoneal dissemination from gastric cancer by peritonectomy and chemohyperthermic peritoneal perfusion. Br J Surg 2005;92:370-5.

10. Glehen O, Gilly FN, Arvieux C, et al. Peritoneal carcinomatosis from gastric cancer: a multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy. Ann Surg Oncol 2010;17:2370-7.

11. Yan TD, Links M, Fransi S, et al. Learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal surface malignancy--a journey to becoming a Nationally Funded Peritonectomy Center. Ann Surg Oncol 2007;14:2270-80.

12. Smeenk RM, Verwaal VJ, Zoetmulder FA. Learning curve of combined modality treatment in peritoneal surface disease. Br J Surg 2007;94:1408-14.

Cite this article as:Morris DL. Peritonectomy HIPEC—contemporary results, indications. Chin J Cancer Res 2013;25(4):373-374. doi: 10.3978/j.issn.1000-9604.2013.07.03

10.3978/j.issn.1000-9604.2013.07.03