亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        Expression and significance of Notch-1 and Jagged-2 in patients with Hirschsprung disease

        2012-08-15 00:54:32JiaHuimin
        外科研究與新技術(shù) 2012年1期

        /Jia Huimin

        (賈慧敏,Dept Pediatr Surg,Shengjing Hosp,Chin Med Univ Key Lab Health Ministry Congeni Malformat,Shenyang 110004)…∥Chin J Gastrointest Surg.-2011,14(8).-768 ~771

        ObjectiveTo investigate the expression of Notch-1 and Jagged-2 in the normal and spastic segments of colon in patients with Hirschsprung disease(HD),and to explore the conrelation of Notch-1 and Jagged-2 with pathogenesis of HD.MethodsFrom 2005 to 2010,resected colon specimens of 30 cases with HD were selected for this study.Normal colonic segments were served as control group,while the transitional and spastic segments as experimental group.Immunohistochemical staining,Western blotting,and RT-PCR were applied to detect the expression of Notch-1 and Jagged-2.ResultsA large number of Notch-1 and Jagged-2 positive gangliocytes were observed in the control group,while none was observed in spastic segments.Significantly less Notch-1 and Jagged-2 positive gangliocytes were found in the transitional segments.Western blotting revealed that Notch-1 and Jagged-2 protein levels in spastic segments(0.19 ±0.02 and 0.13 ±0.04)were less than that in transitional segments and normal segments(0.58 ±0.05 and 0.52 ±0.04,0.72 ± 0.04 and 0.69 ± 0.04,respectively)(P <0.05).RT-PCR revealed that Notch-1 and Jagged-2 mRNA levels were consistent with protein expression.Conclusion Notch-1 and Jagged-2 are not expressed in spastic colon segments,which may be associated with the pathogenesis of HD.12 refs,3 figs,2 tabs.

        亚洲爆乳精品无码一区二区| 五月激情四射开心久久久| 日韩精品人妻久久久一二三| 果冻传媒2021精品一区| 精品国产网红福利在线观看| 久久久精品亚洲懂色av| 亚洲高清一区二区三区在线播放| 日本精品无码一区二区三区久久久| 亚洲国产成人精品女人久久久| 美女被射视频在线观看91| 久久日韩精品一区二区| 巨大巨粗巨长 黑人长吊| 热の国产AV| 亚洲一区二区三区在线| 成人免费在线亚洲视频| 另类老妇奶性生bbwbbw| 综合无码综合网站| 日本午夜a级理论片在线播放| 98色婷婷在线| 国产无遮挡a片又黄又爽| 狠狠色欧美亚洲综合色黑a| 小池里奈第一部av在线观看| 美丽人妻在夫前被黑人| 日韩高清亚洲日韩精品一区| 国产特黄1区2区3区4区| 精品国产一区二区三区av| 国产精品美女久久久久| 99精品国产闺蜜国产在线闺蜜| 白嫩少妇高潮喷水av| 久久久亚洲精品一区二区三区| 国产精品二区在线观看| 成人偷拍自拍在线视频| 伊人情人色综合网站| 国产精品美女久久久久久久久| 久久99久久99精品观看| 国产亚洲精品90在线视频| 精品人妻中文无码av在线| 国产精品亚洲专区在线播放| 日本不卡不二三区在线看| 亚洲欧美日韩精品久久| 亚洲香蕉视频|