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        Efficacy of rituximab-containing regimens on post-transplantation lymphoproliferative disorder following haploidentical hematopoietic stem cell trans-plantatio: reor f 3 css

        2011-08-15 00:54:32XueMeiDeptHematolGenerHospPLAAirForceBeijing100142ChinTransplant201132488491
        外科研究與新技術(shù) 2011年4期

        Xue Mei(薛 梅,Dept Hematol,Gener Hosp PLA Air Force,Beijing 100142)…∥Chin J Transplant.-2011,32(8).-488 ~491

        Efficacy of rituximab-containing regimens on post-transplantation lymphoproliferative disorder following haploidentical hematopoietic stem cell trans-plantatio: reor f 3 css

        Xue Mei(薛 梅,Dept Hematol,Gener Hosp PLA Air Force,Beijing 100142)…∥Chin J Transplant.-2011,32(8).-488 ~491

        ObjectiveTo evaluate the efficacy of rituximabcontaining regimens on post- transplantation lymphoproliferative disorder(PTLD)following haploidentical hematopoietic stem cell transplantation(HSCT).MethodsThe clinical data of 3 cases of PTLD after haploidentical HSCT were analyzed retrospectively.Time to development of PTLD ranged from 57 to 164 days after HSCT.The main symptoms included fever,superficial lymph node enlargement.Epstein-Parr virus(EBV)-positive B - cell PTLD was,diagnosed by biopsy of lymph node.Management of 3 patients consisted of withdraw of immunosuppressive treatment,anti - viral therapy,rituximab(375 mg/m2,per week for four weeks)monotherapy or chemotherapy plus rituximab.ResultsAll the patients recovered after treatment.ConclusionPTLD is a serious complication of HSCT especially haploidentical HSCT.Rituximab-containing regimens are potentially effective,well- tolerated with mild toxicity and can improve the prognosis of PTLD following haploidentical HSCT.8 refs.

        (Authors)

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